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Musculoskeletal

Our musculoskeletal system comprises the structural foundation that enables all essential internal and external bodily motion. In cases of injury, our ability to move and execute essential aspects of daily life is significantly impaired, causing psychological, physical distress, and loss of productivity. The musculoskeletal system relies on diverse tissues with distinct properties that carefully interface together to harmoniously function. Regenerating these tissues, such as cartilage, ligaments, tendons or bone, requires diverse strategies that recognize individual tissue characteristics as transitions zones from one tissue to another in order to restore holistic function. Strategies for recapitulating structural integrity of the musculoskeletal system include designing complex 3D-printed scaffolds with spatially variable bioactivity, injectable biomaterials that phase change to provide structural and cellular support, and innovation in the design of anti-inflammatory biomaterials.

Yuan Luo

Yuan Luo

Director, Institute for Artificial Intelligence in Medicine – Center for Collaborative AI in Healthcare
Professor, Preventive Medicine (Biostatistics and Informatics), Pediatrics
Professor, McCormick School of Engineering